Hypoadiponectinemia and Cancers

Low levels of plasma adiponectin are closely correlated with several obesity- and insulin resistance-related cancers. A strong inverse association between plasma adiponectin levels and the risk of both breast cancer and endometrial cancer has recently been reported in two case-control studies (99,100). Importantly, these associations are independent of adiposity, insulin resistance, and other classical risk factors. Another study by Miyoshi et al. has shown that breast cancers arising in women with low adiponectin levels are more likely to show a biologically aggressive phenotype (101). Plasma adiponectin levels in patients with gastric cancer, especially those with upper gastric cancer, were also reported to be much lower than in control subjects (102). Interestingly, in patients with undifferentiated cancer, serum adiponectin showed a negative correlation with pathological findings such as tumor size, depth of invasion, as well as tumor stage. In a large prospective study comprising 18,225 subjects, hypoadiponectinemia was found to be an independent predictor for the future development of colorectal cancer (103). Together these data suggest that adiponectin deficiency might partly account for the increased risk of the aforementioned cancers in obese and insulin resistant subjects.

Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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