Recent results from a large American Cancer Society prospective mortality study illustrate that increased body weight is associated with increased death rates from all cancers combined and for cancers at multiple specific sites in both men and women (Figs. 1,2). These results were based on a population of more than 900,000 US adults who were followed from 1982 through 1998, and on more than 57,000 deaths from cancer that occurred during the 16-yr follow-up period (3). The results are based on cancer mortality and thus may reflect the influence of BMI on either cancer incidence or survival, or both.
Survival may be influenced by adiposity-related differences in diagnosis or treatment of cancer, as well as by true biological effects of adiposity on cancer progression.
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