Integrin Linked Kinase

Integrin-linked kinase (ILK) is an ubiquitously expressed serine/threonine kinase that binds to the cytoplasmic domain of the pi integrin subunit.98 It is involved in the regulation of cell survival and plays a role in cancer, with its upregula-tion identified in cancers of the colon, breast, prostate, and lung, and in melanoma.28,35-38 ILK is upregulated, often in a stage- and grade-dependent manner, and is associated with metastases.28 ILK is a central structural and signaling protein that serves as a link between the extracellular matrix and the cytoskeleton via integrins, paxillin, and parvins, and with adaptor proteins particularly interesting new cysteine-histi-dine-rich protein (PINCH) and Nck2, and between integrins and receptor tyrosine kinases.28,39,40 It also activates various signaling pathways through its kinase activity.28

0 0

Post a comment