Ii

Induce strong IgG responses that cross the placenta and persist in the newborn for at least 2 to 3 months, the period of maximum susceptibility (Baker and Kasper 1976). Surprisingly, despite the fact that the former GBSP conjugates share extensive structural homology with human tissue antigens, they are still able to induce in humans strong IgG responses to their respective polysaccharides. This can be explained in the case of types Ia, II and III GBSP because they are able to form...

Harold J Jennings

The capsular polysaccharides of human pathogenic bacteria are strong virulence factors and their use as human vaccines are well established (Jennings 1983). Some bacteria have acquired the ability to incorporate sialic acid into their capsules which further enables them to evade the human immune system. For example, the presence of sialic acid enhances the ability of bacteria to mimic human sialylated antigens, which are ubiquitous on normal human cells, giving them the ability to downregulate...

Synthesis of the Hexasaccharide Repeating Unit

The retrosynthetic analysis of the fully protected hexasaccharide 39 (Scheme 2.5) dissected the target molecule into two terminal a-galactose building blocks 41, 42, Scheme 2.5 Retrosynthetic analysis of a hexasaccharide repeating unit of the capsular polysaccharide of B. anthracis Scheme 2.5 Retrosynthetic analysis of a hexasaccharide repeating unit of the capsular polysaccharide of B. anthracis and two disaccharide parts A and B. For part A, two building blocks 40 and 42 were identified. The...

Ryan J Blackler Sven Mller Loennies Lore Brade Paul Kosma Helmut Brade and Stephen V Evans

The atomic coordinates and structure factors for all structures discussed have been deposited in the Protein Data Bank, Research Collaboratory for Structural Bioinformatics, Rutgers University, New Brunswick NJ (http www.rcsb.org). See Table 4.1. The increasing utility of carbohydrate-specific antibodies in diagnostic and therapeutic medicine, in disease bio-marker identification, and in carbohydrate-based vaccine design has underlined the need to understand these important interactions at the...

Immune Recognition of Ogawa and Inaba LPSs 1221 On the Antigenic Determinants

Rabbit and mouse antisera allowed to distinguish three antigenic determinants (A, B, and C) present in Ogawa or Inaba LPSs. One of these determinants, i.e. motif A, is expressed substantially by both serotypes. In addition, Ogawa LPS displays the C epitope, but to a lesser extent than Inaba LPS, whereas the latter lacks the B epitope (Chatterjee and Chaudhuri 2006). Murine mAbs representative of the three classes of V. cholerae O1 dLPS-epitope specificity have been isolated (Gustafsson and...