CD8 T cells in neuroinflammation A neverending controversy

Neuroinflammation Model

The debate about the role of CD8+ T cells in chronic neuroinflammation was started by histopathologic studies of active and chronic MS lesions, showing inconsistent results for both numbers and distribution in MS lesions. In some patients' biopsies, large numbers of oligoclonally expanded CD8+ T cells prevailed within active demyelinating lesions (Babbe et al., 2000), while others presented with scarce, often only marginal infiltration of chronic active MS lesions by CD8+ T cells (Traugott et...