Contents

Guide To Beating Hypoglycemia

Foods not to eat if you have Hypoglycemia

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1 Introduction 1

Denson G. Fujikawa

Part I Caspase-Independent Programmed Cell Death: General Considerations

2 Caspase-Independent Cell Death Mechanisms in Simple Animal Models 9

Matthias Rieckher and Nektarios Tavernarakis

3 Programmed Necrosis: A "New" Cell Death Outcome for Injured Adult Neurons? 35

Slavica Krantic and Santos A. Susin

4 Age-Dependence of Neuronal Apoptosis and of Caspase Activation 67

Denson G. Fujikawa

5 Excitotoxic Programmed Cell Death Involves Caspase-Independent Mechanisms 79

Ho Chul Kang, Ted M. Dawson, and Valina L. Dawson

Part II Focal Cerebral Ischemia

6 Significant Role of Apoptosis-Inducing Factor (AIF) for Brain Damage Following Focal Cerebral Ischemia 91

Nikolaus Plesnila and Carsten Culmsee

7 The Role of Poly(ADP-Ribose) Polymerase-1 (PARP-1)

Activation in Focal Cerebral Ischemia 103

Giuseppe Faraco and Alberto Chiarugi

Part III Transient Global Ischemia

8 Transient Global Cerebral Ischemia Produces Morphologically Necrotic, Not Apoptotic Neurons 121

Frederick Colbourne and Roland N. Auer

9 Apoptosis-Inducing Factor Translocation to Nuclei

After Transient Global Ischemia 131

Can Liu, Armando P. Signore, Guodong Cao, and Jun Chen

10 Role of ^-Calpain I and Lysosomal Cathepsins in Hippocampal Neuronal Necrosis After Transient Global Ischemia in Primates 145

Anton B. Tonchev and Tetsumori Yamashima

Part IV Traumatic Central Nervous System (CNS) Injury

11 Mitochondrial Damage in Traumatic CNS Injury 157

Laurie M. Davis and Patrick G. Sullivan

12 Programmed Neuronal Cell Death Mechanisms in CNS Injury 169

Bogdan A. Stoica and Alan I. Faden

Part V Hypoglycemic Neuronal Death

13 Hypoglycemic Brain Damage 203

Roland N. Auer

14 Hypoglycemic Neuronal Death 211

Raymond A. Swanson and Sang Won Suh

Part VI Seizure-Induced Neuronal Death

15 Tumor Suppressor p53: A Multifunctional Protein

Implicated in Seizure-Induced Neuronal Cell Death 231

Zhiqun Tan and Steven S. Schreiber

16 DNA Damage and Repair in the Brain: Implications for Seizure-Induced Neuronal Injury, Endangerment, and Neuroprotection 243

Samantha L. Crowe and Alexei D. Kondratyev

17 Activation of Caspase-Independent Programmed

Pathways in Seizure-Induced Neuronal Necrosis 277

Denson G. Fujikawa

Concluding Remarks 295

Denson G. Fujikawa

Index

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