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Abraham MC, Lu Y, Shaham S (2007) A morphologically conserved nonapoptotic program promotes linker cell death in Caenorhabditis elegans. Dev Cell 12:73-86 Antignani A, Youle RJ (2006) How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane? Curr Opin Cell Biol 18:685-689 Arnoult D, Gaume B, Karbowski M, Sharpe JC, Cecconi F, Youle RJ (2003) Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization. EMBO J 22:4385-4399 Artal-Sanz M, Tavernarakis N (2005) Proteolytic mechanisms in necrotic cell death and neurodegeneration. FEBS Lett 579:3287-3296 Artal-Sanz M, Samara C, Syntichaki P, Tavernarakis N (2006) Lysosomal biogenesis and function is critical for necrotic cell death in Caenorhabditis elegans. J Cell Biol 173:231-239 Baehrecke EH (2003) Autophagic programmed cell death in Drosophila. Cell Death Differ 10:940-945

Baehrecke EH (2005) Autophagy: dual roles in life and death? Nat Rev Mol Cell Biol 6:505-510 Bargmann CI, Avery L (1995) Laser killing of cells in Caenorhabditis elegans. Methods Cell Biol 48:225-250

Beart PM, O'Shea RD (2007) Transporters for L-glutamate: an update on their molecular pharmacology and pathological involvement. Br J Pharmacol 150:5-17 Berger AJ, Hart AC, Kaplan JM (1998) G alphas-induced neurodegeneration in Caenorhabditis elegans. J Neurosci 18:2871-2880

Berger J, Suzuki T, Senti KA, Stubbs J, Schaffner G, Dickson BJ (2001) Genetic mapping with

SNP markers in Drosophila. Nat Genet 29:475-481 Blumenthal T, Evans D, Link CD, Guffanti A, Lawson D, Thierry-Mieg J, Thierry-Mieg D, Chiu WL, Duke K, Kiraly M, Kim SK (2002) A global analysis of Caenorhabditis elegans operons. Nature 417:851-854

Brand AH, Perrimon N (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118:401-415 Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77:71-94 Broker LE, Kruyt FA, Giaccone G (2005) Cell death independent of caspases: a review. Clin

Cancer Res 11:3155-3162 Carthew RW (2007) Pattern formation in the Drosophila eye. Curr Opin Genet Dev 17:309-313 Cauchi RJ, van den Heuvel M (2006) The fly as a model for neurodegenerative diseases: is it worth the jump? Neurodegener Dis 3:338-356 Celotto AM, Palladino MJ (2005) Drosophila: a "model" model system to study neurodegeneration. Mol Interv 5:292-303 Chalfie M, Wolinsky E (1990) The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans. Nature 345:410-416 Challa M, Malladi S, Pellock BJ, Dresnek D, Varadarajan S, Yin YW, White K, Bratton SB (2007) Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease. EMBO J 26:3144-3156

Clarke PG (1990) Developmental cell death: morphological diversity and multiple mechanisms.

Anat Embryol (Berl) 181:195-213 Cote J, Ruiz-Carrillo A (1993) Primers for mitochondrial DNA replication generated by endonu-

clease G. Science 261:765-769 Coulson A, Waterston R, Kiff J, Sulston J, Kohara Y (1988) Genome linking with yeast artificial chromosomes. Nature 335:184-186 Danial NN, Korsmeyer SJ (2004) Cell death: critical control points. Cell 116:205-219 del Peso L, Gonzalez VM, Inohara N, Ellis RE, Nunez G (2000) Disruption of the CED-9.CED-4 complex by EGL-1 is a critical step for programmed cell death in Caenorhabditis elegans. J Biol Chem 275:27205-27211 Driscoll M, Gerstbrein B (2003) Dying for a cause: invertebrate genetics takes on human neurodegeneration. Nat Rev Genet 4:181-194 Edinger AL, Thompson CB (2004) Death by design: apoptosis, necrosis and autophagy. Curr Opin Cell Biol 16:663-669

Ellis HM, Horvitz HR (1986) Genetic control of programmed cell death in the nematode C. elegans. Cell 44:817-829

Estaquier J, Arnoult D (2006) CED-9 and EGL-1: a duo also regulating mitochondrial network morphology. Mol Cell 21:730-732 Faber PW, Voisine C, King DC, Bates EA, Hart AC (2002) Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity. Proc Natl Acad Sci USA 99:17131-17136 Furuya N, Yu J, Byfield M, Pattingre S, Levine B (2005) The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy 1:46-52

Golic KG (1991) Site-specific recombination between homologous chromosomes in Drosophila. Science 252:958-961

Gorski SM, Chittaranjan S, Pleasance ED, Freeman JD, Anderson CL, Varhol RJ, Coughlin SM, Zuyderduyn SD, Jones SJ, Marra MA (2003) A SAGE approach to discovery of genes involved in autophagic cell death. Curr Biol 13:358-363 Green DR, Kroemer G (2004) The pathophysiology of mitochondrial cell death. Science 305:626-629

Greenspan RJ (1997) Fly pushing. Cold Spring Harbor Laboratory Press, New York

Hall DH, Russell RL (1991) The posterior nervous system of the nematode Caenorhabditis elegans: serial reconstruction of identified neurons and complete pattern of synaptic interactions. J Neurosci 11:1-22

Halligan DL, Keightley PD (2006) Ubiquitous selective constraints in the Drosophila genome revealed by a genome-wide interspecies comparison. Genome Res 16:875-884 Hartl DL, Ajioka JW, Cai H, Lohe AR, Lozovskaya ER, Smoller DA, Duncan IW (1992) Towards a Drosophila genome map. Trends Genet 8:70-75 Hay BA, Guo M (2006) Caspase-dependent cell death in Drosophila. Annu Rev Cell Dev Biol 22:623-650

Hengartner MO (2000) The biochemistry of apoptosis. Nature 407:770-776 Hersh BM, Hartwieg E, Horvitz HR (2002) The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types. Proc Natl Acad Sci USA 99:4355-4360

Igaki T, Miura M (2004) Role of Bcl-2 family members in invertebrates. Biochim Biophys Acta 1644:73-81

Igaki T, Suzuki Y, Tokushige N, Aonuma H, Takahashi R, Miura M (2007) Evolution of mitochondrial cell death pathway: Proapoptotic role of HtrA2/Omi in Drosophila. Biochem Biophys Res Commun 356:993-997 Jakubowski J, Kornfeld K (1999) A local, high-density, single-nucleotide polymorphism map used to clone Caenorhabditis elegans cdf-1. Genetics 153:743-752 Jin Y (2005) C. elegans - a practical approach. Oxford University press, Oxford Juhasz G, Sass M (2005) Hid can induce, but is not required for autophagy in polyploid larval

Drosophila tissues. Eur J Cell Biol 84:491-502 Juhasz G, Erdi B, Sass M, Neufeld TP (2007a) Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila. Genes Dev 21:3061-3066 Juhasz G, Puskas LG, Komonyi O, Erdi B, Maroy P, Neufeld TP, Sass M (2007b) Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body. Cell Death Differ 14:1181-1190 Kamada Y, Funakoshi T, Shintani T, Nagano K, Ohsumi M, Ohsumi Y (2000) Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol 150:1507-1513 Kang C, You YJ, Avery L (2007) Dual roles of autophagy in the survival of Caenorhabditis ele-

gans during starvation. Genes Dev 21:2161-2171 Kerr JF, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wideranging implications in tissue kinetics. Br J Cancer 26:239-257 Kim R, Emi M, Tanabe K (2006) Role of mitochondria as the gardens of cell death. Cancer

Chemother Pharmacol 57:545-553 Klein JA, Longo-Guess CM, Rossmann MP, Seburn KL, Hurd RE, Frankel WN, Bronson RT, Ackerman SL (2002) The harlequin mouse mutation downregulates apoptosis-inducing factor. Nature 419:367-374 Klionsky DJ (2004) Cell biology: regulated self-cannibalism. Nature 431:31-32 Klionsky DJ (2005) The molecular machinery of autophagy: unanswered questions. J Cell Sci 118:7-18

Klionsky DJ (2007) Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol 8:931-937 Klionsky DJ, Cregg JM, Dunn WA Jr, Emr SD, Sakai Y, Sandoval IV, Sibirny A, Subramani S, Thumm M, Veenhuis M, Ohsumi Y (2003) A unified nomenclature for yeast autophagy-related genes. Dev Cell 5:539-545 Kornberg TB, Krasnow MA (2000) The Drosophila genome sequence: implications for biology and medicine. Science 287:2218-2220 Korswagen HC, van der Linden AM, Plasterk RH (1998) G protein hyperactivation of the Caenorhabditis elegans adenylyl cyclase SGS-1 induces neuronal degeneration. EMBO J 17:5059-5065

Kourtis N, Tavernarakis N (2007) Non-developmentally programmed cell death in Caenorhabditis elegans. Semin Cancer Biol 17:122-133 Krantic S, Mechawar N, Reix S, Quirion R (2007) Apoptosis-inducing factor: a matter of neuron life and death. Prog Neurobiol 81:179-196 Kroemer G, Martin SJ (2005) Caspase-independent cell death. Nat Med 11:725-730 Kumar A, Rothman JH (2007) Cell death: hook, line and linker. Curr Biol 17:R286-R289 Lakovaara S (1969) Malt as a culture medium for Drosophila species. Drosoph Inf Serv 44:128 Lawrence PA (1992) The making of a fly. The genetics of animal design, 1st edn. Blackwell, Oxford Lee ST, Kim M (2006) Aging and neurodegeneration. Molecular mechanisms of neuronal loss in

Huntington's disease. Mech Ageing Dev 127:432-435 Lee CY, Clough EA, Yellon P, Teslovich TM, Stephan DA, Baehrecke EH (2003) Genome-wide analyses of steroid- and radiation-triggered programmed cell death in Drosophila. Curr Biol 13:350-357

Lee J, Nam S, Hwang SB, Hong M, Kwon JY, Joeng KS, Im SH, Shim J, Park MC (2004) Functional genomic approaches using the nematode Caenorhabditis elegans as a model system. J Biochem Mol Biol 37:107-113 Leist M, Jaattela M (2001) Four deaths and a funeral: from caspases to alternative mechanisms.

Nat Rev Mol Cell Biol 2:589-598 Lettre G, Hengartner MO (2006) Developmental apoptosis in C. elegans: a complex CEDnario.

Nat Rev Mol Cell Biol 7:97-108 Leyssen M, Hassan BA (2007) A fruitfly's guide to keeping the brain wired. EMBO Rep 8:46-50

Li W, Baker NE (2007) Engulfment is required for cell competition. Cell 129:1215-1225 Li LY, Luo X, Wang X (2001) Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 412:95-99 Lim HY, Bodmer R, Perrin L (2006) Drosophila aging 2005/06. Exp Gerontol 41:1213-1216 Lin CY, Chen SH, Cho CS, Chen CL, Lin FK, Lin CH, Chen PY, Lo CZ, Hsiung CA (2006) Fly-DPI: database of protein interactomes for D. melanogaster in the approach of systems biology. BMC Bioinformatics 7(Suppl 5):S18 Lindmo K, Stenmark H (2006) How a RING finger protein and a steroid hormone control autophagy. Autophagy 2:321-322 Lindmo K, Simonsen A, Brech A, Finley K, Rusten TE, Stenmark H (2006) A dual function for Deep orange in programmed autophagy in the Drosophila melanogaster fat body. Exp Cell Res 312:2018-2027

Lorenzo HK, Susin SA (2004) Mitochondrial effectors in caspase-independent cell death. FEBS Lett 557:14-20

Majeski AE, Dice JF (2004) Mechanisms of chaperone-mediated autophagy. Int J Biochem Cell Biol 36:2435-2444

Martin DN, Baehrecke EH (2004) Caspases function in autophagic programmed cell death in

Drosophila. Development 131:275-284 Martin DN, Balgley B, Dutta S, Chen J, Rudnick P, Cranford J, Kantartzis S, DeVoe DL, Lee C, Baehrecke EH (2007) Proteomic analysis of steroid-triggered autophagic programmed cell death during Drosophila development. Cell Death Differ 14:916-923 Mazzalupo S, Cooley L (2006) Illuminating the role of caspases during Drosophila oogenesis.

Cell Death Differ 13:1950-1959 McCall K (2004) Eggs over easy: cell death in the Drosophila ovary. Dev Biol 274:3-14 Melendez A, Talloczy Z, Seaman M, Eskelinen EL, Hall DH, Levine B (2003) Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 301:1387-1391

Mello CC, Conte D Jr (2004) Revealing the world of RNA interference. Nature 431:338-342 Mello C, Fire A (1995) Methods in cell biology: Caenorhabditis elegans: modern biological analysis of an organism. Academic, San Diego, p 451 Mergliano J, Minden JS (2003) Caspase-independent cell engulfment mirrors cell death pattern in Drosophila embryos. Development 130:5779-5789

Miramar MD, Costantini P, Ravagnan L, Saraiva LM, Haouzi D, Brothers G, Penninger JM, Peleato ML, Kroemer G, Susin SA (2001) NADH oxidase activity of mitochondrial apoptosis-inducing factor. J Biol Chem 276:16391-16398 Modjtahedi N, Giordanetto F, Madeo F, Kroemer G (2006) Apoptosis-inducing factor: vital and lethal. Trends Cell Biol 16:264-272 Munoz-Pinedo C, Guio-Carrion A, Goldstein JC, Fitzgerald P, Newmeyer DD, Green DR (2006) Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration. Proc Natl Acad Sci USA 103:11573-11578

Murakami S (2007) Caenorhabditis elegans as a model system to study aging of learning and memory. Mol Neurobiol 35:85-94 Nakano Y, Fujitani K, Kurihara J, Ragan J, Usui-Aoki K, Shimoda L, Lukacsovich T, Suzuki K, Sezaki M, Sano Y, Ueda R, Awano W, Kaneda M, Umeda M, Yamamoto D (2001) Mutations in the novel membrane protein spinster interfere with programmed cell death and cause neural degeneration in Drosophila melanogaster. Mol Cell Biol 21:3775-3788 Nass R, Hall DH, Miller DM 3rd, Blakely RD (2002) Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans. Proc Natl Acad Sci USA 99:3264-3269 Neufeld TP (2007) Contribution of Atg1-dependent autophagy to TOR-mediated cell growth and survival. Autophagy 3:477-479 Nicotera P, Leist M, Manzo L (1999) Neuronal cell death: a demise with different shapes. Trends

Pharmacol Sci 20:46-51 Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N (2002) A novel p53-inducible apop-togenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF). FEBS Lett 524:163-171

O'Keefe LV, Liu Y, Perkins A, Dayan S, Saint R, Richards RI (2005) FRA16D common chromosomal fragile site oxido-reductase (FOR/WWOX) protects against the effects of ionizing radiation in Drosophila. Oncogene 24:6590-6596 Olney JW (1994) Excitatory transmitter neurotoxicity. Neurobiol Aging 15:259-260 Pandey UB, Nie Z, Batlevi Y, McCray BA, Ritson GP, Nedelsky NB, Schwartz SL, DiProspero NA, Knight MA, Schuldiner O, Padmanabhan R, Hild M, Berry DL, Garza D, Hubbert CC, Yao TP, Baehrecke EH, Taylor JP (2007) HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 447:859-863 Parrish JZ, Xue D (2003) Functional genomic analysis of apoptotic DNA degradation in C. elegans. Mol Cell 11:987-996 Parrish J, Li L, Klotz K, Ledwich D, Wang X, Xue D (2001) Mitochondrial endonuclease G is important for apoptosis in C. elegans. Nature 412:90-94 Parrish JZ, Yang C, Shen B, Xue D (2003) CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation. EMBO J 22:3451-3460

Porter AG, Urbano AG (2006) Does apoptosis-inducing factor (AIF) have both life and death functions in cells? Bioessays 28:834-843 Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, Oroz LG, Scaravilli F, Easton DF, Duden R, O'Kane CJ, Rubinsztein DC (2004) Inhibition of mTOR induces autophagy and reduces toxic-ity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet 36:585-595

Riddle D (1988) The nematode C. elegans. Cold Spring Harbor Laboratory Press, New York, pp 393-412

Riddle DL, Gorski SM (2003) Shaping and stretching life by autophagy. Dev Cell 5:364-365 Riddle DL, Blumenthal T, Meyer BJ, Priess JR (1997) C. elegans II. Cold Spring Harbor

Laboratory Press, New York Rieckher M, Kourtis N, Pasparaki A, Tavernarakis N (2009) Transgenesis in Caenorhabditis ele-gans. Method Mol Biol 561:21-39

Rival T, Soustelle L, Strambi C, Besson MT, Iche M, Birman S (2004) Decreasing glutamate buffering capacity triggers oxidative stress and neuropil degeneration in the Drosophila brain. Curr Biol 14:599-605

Roudier N, Lefebvre C, Legouis R (2005) CeVPS-27 is an endosomal protein required for the molting and the endocytic trafficking of the low-density lipoprotein receptor-related protein 1 in Caenorhabditis elegans. Traffic 6:695-705 Rubinsztein DC, Gestwicki JE, Murphy LO, Klionsky DJ (2007) Potential therapeutic applications of autophagy. Nat Rev Drug Discov 6:304-312 Rusten TE, Lindmo K, Juhasz G, Sass M, Seglen PO, Brech A, Stenmark H (2004) Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. Dev Cell 7:179-192 Samara C, Tavernarakis N (2008) Autophagy and cell death in Caenorhabditis elegans. Curr Pharm Des 14:1-19

Samara C, Syntichaki P, Tavernarakis N (2008) Autophagy is required for necrotic cell death in

Caenorhabditis elegans. Cell Death Differ 15(1):105-112 Sarkar S, Perlstein EO, Imarisio S, Pineau S, Cordenier A, Maglathlin RL, Webster JA, Lewis TA, O'Kane CJ, Schreiber SL, Rubinsztein DC (2007) Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol 3:331-338 Schmitz C, Kinge P, Hutter H (2007) Axon guidance genes identified in a large-scale RNAi screen using the RNAi-hypersensitive Caenorhabditis elegans strain nre-1(hd20) lin-15b(hd126). Proc Natl Acad Sci USA 104:834-839 Scott BA, Avidan MS, Crowder CM (2002) Regulation of hypoxic death in C. elegans by the insulin/IGF receptor homolog DAF-2. Science 296:2388-2391 Scott RC, Schuldiner O, Neufeld TP (2004) Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev Cell 7:167-178 Scott RC, Juhasz G, Neufeld TP (2007) Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death. Curr Biol 17:1-11 Simmer F, Moorman C, van der Linden AM, Kuijk E, van den Berghe PV, Kamath RS, Fraser AG, Ahringer J, Plasterk RH (2003) Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. PLoS Biol 1:E12 Simonsen A, Cumming RC, Brech A, Isakson P, Schubert DR, Finley KD (2008) Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy 4(2):176-184 Spradling AC, Stern DM, Kiss I, Roote J, Laverty T, Rubin GM (1995) Gene disruptions using P transposable elements: an integral component of the Drosophila genome project. Proc Natl Acad Sci USA 92:10824-10830 Stefanis L (2005) Caspase-dependent and -independent neuronal death: two distinct pathways to neuronal injury. Neuroscientist 11:50-62 Sulston JE, Albertson DG, Thomson JN (1980) The Caenorhabditis elegans male: postembryonic development of nongonadal structures. Dev Biol 78:542-576 Sulston JE, Schierenberg E, White JG, Thomson JN (1983) The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev Biol 100:64-119 Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Aebersold R, Siderovski DP, Penninger JM, Kroemer G (1999) Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397:441-446

Suzuki Y, Imai Y, Nakayama H, Takahashi K, Takio K, Takahashi R (2001) A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol Cell 8:613-621

Syntichaki P, Tavernarakis N (2002) Death by necrosis. Uncontrollable catastrophe, or is there order behind the chaos? EMBO Rep 3:604-609 Syntichaki P, Tavernarakis N (2003) The biochemistry of neuronal necrosis: rogue biology? Nat Rev Neurosci 4:672-684

Syntichaki P, Tavernarakis N (2004) Genetic models of mechanotransduction: the nematode

Caenorhabditis elegans. Physiol Rev 84:1097-1153 Syntichaki P, Xu K, Driscoll M, Tavernarakis N (2002) Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans. Nature 419:939-944 Syntichaki P, Samara C, Tavernarakis N (2005) The vacuolar H+ -ATPase mediates intracellular acidification required for neurodegeneration in C. elegans. Curr Biol 15:1249-1254 Tabata T, Takei Y (2004) Morphogens, their identification and regulation. Development 131:703-712

Takacs-Vellai K, Vellai T, Puoti A, Passannante M, Wicky C, Streit A, Kovacs AL, Muller F (2005) Inactivation of the autophagy gene bec-1 triggers apoptotic cell death in C. elegans. Curr Biol 15:1513-1517 Tavernarakis N, Driscoll M (2001) Degenerins. At the core of the metazoan mechanotransducer?

Ann N Y Acad Sci 940:28-41 Tavernarakis N, Wang SL, Dorovkov M, Ryazanov A, Driscoll M (2000) Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes. Nat Genet 24:180-183 Thomas JH, Lockery S (2005) C. elegans - a practical approach: neurobiology. Oxford University press, Oxford

Thumm M, Kadowaki T (2001) The loss of Drosophila APG4/AUT2 function modifies the phe-

notypes of cut and Notch signaling pathway mutants. Mol Genet Genomics 266:657-663 Toth ML, Simon P, Kovacs AL, Vellai T (2007) Influence of autophagy genes on ion-channel-

dependent neuronal degeneration in Caenorhabditis elegans. J Cell Sci 120:1134-1141 Varkey J, Chen P, Jemmerson R, Abrams JM (1999) Altered cytochrome c display precedes apop-

totic cell death in Drosophila. J Cell Biol 144:701-710 Vaux DL, Korsmeyer SJ (1999) Cell death in development. Cell 96:245-254 Venken KJ, Bellen HJ (2005) Emerging technologies for gene manipulation in Drosophila mela-

nogaster. Nat Rev Genet 6:167-178 Walhout AJ, Sordella R, Lu X, Hartley JL, Temple GF, Brasch MA, Thierry-Mieg N, Vidal M (2000) Protein interaction mapping in C. elegans using proteins involved in vulval development. Science 287:116-122 Wang CW, Klionsky DJ (2003) The molecular mechanism of autophagy. Mol Med 9:65-76 Wang X, Yang C, Chai J, Shi Y, Xue D (2002) Mechanisms of AIF-mediated apoptotic DNA

degradation in Caenorhabditis elegans. Science 298:1587-1592 Wang X, Wang J, Gengyo-Ando K, Gu L, Sun CL, Yang C, Shi Y, Kobayashi T, Shi Y, Mitani S, Xie XS, Xue D (2007) C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1. Nat Cell Biol 9:541-549

Wang X, Yang C, Xue D (unpublished results)

Waterston R, Sulston J (1995) The genome of Caenorhabditis elegans. Proc Natl Acad Sci USA 92:10836-10840

White JG, Southgate E, Thomson JN, Brenner S (1983) Factors that determine connectivity in the nervous system of Caenorhabditis elegans. Cold Spring Harb Symp Quant Biol 48(Pt 2):633-640

Wu M, Xu LG, Li X, Zhai Z, Shu HB (2002) AMID, an apoptosis-inducing factor-homologous mitochondrion-associated protein, induces caspase-independent apoptosis. J Biol Chem 277:25617-25623

Xiang H, Hochman DW, Saya H, Fujiwara T, Schwartzkroin PA, Morrison RS (1996) Evidence for p53-mediated modulation of neuronal viability. J Neurosci 16:6753-6765 Xu K, Tavernarakis N, Driscoll M (2001) Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca(2+) release from the endoplasmic reticulum. Neuron 31:957-971

Yamashima T (2000) Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates. Prog Neurobiol 62:273-295

Yamashima T (2004) Ca2+-dependent proteases in ischemic neuronal death: a conserved 'calpain-

cathepsin cascade' from nematodes to primates. Cell Calcium 36:285-293 Yanagisawa H, Miyashita T, Nakano Y, Yamamoto D (2003) HSpin1, a transmembrane protein interacting with Bcl-2/Bcl-xL, induces a caspase-independent autophagic cell death. Cell Death Differ 10:798-807 Ye H, Cande C, Stephanou NC, Jiang S, Gurbuxani S, Larochette N, Daugas E, Garrido C, Kroemer G, Wu H (2002) DNA binding is required for the apoptogenic action of apoptosis inducing factor. Nat Struct Biol 9:680-684 Yorimitsu T, Klionsky DJ (2007) Eating the endoplasmic reticulum: quality control by autophagy.

Trends Cell Biol 17:279-285 Yuste VJ, Moubarak RS, Delettre C, Bras M, Sancho P, Robert N, D'Alayer J, Susin SA (2005) Cysteine protease inhibition prevents mitochondrial apoptosis-inducing factor (AIF) release. Cell Death Differ 12:1445-1448 Zhou Z, Mangahas PM, Yu X (2004) The genetics of hiding the corpse: engulfment and degradation of apoptotic cells in C. elegans and D. melanogaster. Curr Top Dev Biol 63:91-143

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