Denson G. Fujikawa, MD

Department of Veteran Affairs

VA Greater Los Angeles Healthcare System

16111 Plummer St

North Hills, CA 91343

Department of Neurology

David Geffen School of Medicine

University of California, Los Angeles

710 Westwood Plaza

Los Angeles, CA 90095

[email protected]

ISBN 978-0-387-73225-1 e-ISBN 978-0-387-73226-8

DOI 10.1007/978-0-387-73226-8

Springer New York Dordrecht Heidelberg London

Library of Congress Control Number: 2009930360

© Springer Science+Business Media, LLC 2010

All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights.

Cover illustration: The cover shows neurons in the piriform cortex of a control rat and a rat 24 hours after generalized seizures, showing seizure-induced translocation of endonuclease G (endoG) from cytoplasmic mitochondria to nuclei. The mitochondrial endoG is red and nuclei are blue in the control brain. Following seizures, nuclei appear purplish-white because of movement of endoG to nuclei.

Printed on acid-free paper

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This book would not have been possible without the pioneering work of John W. Olney, MD, to whom it is dedicated

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