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Fig. 1. Acanthosis nigrican. Nape of the neck in a black (A) and white (B) woman and (C) in the axilla of the white woman. The patches of cutaneous hyperpigmentation in these locations are indicative of acanthosis nigricans.

zation in all differentiated cells. Mutations in lamins A and C, which are alternatively spliced products of the lamin A/C (LMNA) gene, are responsible for several genetic diseases, including familial partial lipodystrophy of the Dunnigan type (FPLD). Women with FPLD often have irregular menses and hyperandrogenemiaas well as severe insulin resistance, dyslipidemia, and atherosclerotic vascular disease, similar to patients with the type A syndrome.

  1. 2. Acanthosis nigricans—microscopic. The photomicrograph demonstrates the typical histological features in the affected epidermis, which demonstrates irregular hyperplasia with prominent rete ridges, epidermal hyperpigmentation, and moderate ortho/parakeratotic hyperkeratosis, with no significant inflammatory infiltrate.
  2. 2. Acanthosis nigricans—microscopic. The photomicrograph demonstrates the typical histological features in the affected epidermis, which demonstrates irregular hyperplasia with prominent rete ridges, epidermal hyperpigmentation, and moderate ortho/parakeratotic hyperkeratosis, with no significant inflammatory infiltrate.
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