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Fig. 1. Acanthosis nigrican. Nape of the neck in a black (A) and white (B) woman and (C) in the axilla of the white woman. The patches of cutaneous hyperpigmentation in these locations are indicative of acanthosis nigricans.

zation in all differentiated cells. Mutations in lamins A and C, which are alternatively spliced products of the lamin A/C (LMNA) gene, are responsible for several genetic diseases, including familial partial lipodystrophy of the Dunnigan type (FPLD). Women with FPLD often have irregular menses and hyperandrogenemiaas well as severe insulin resistance, dyslipidemia, and atherosclerotic vascular disease, similar to patients with the type A syndrome.

  1. 2. Acanthosis nigricans—microscopic. The photomicrograph demonstrates the typical histological features in the affected epidermis, which demonstrates irregular hyperplasia with prominent rete ridges, epidermal hyperpigmentation, and moderate ortho/parakeratotic hyperkeratosis, with no significant inflammatory infiltrate.
  2. 2. Acanthosis nigricans—microscopic. The photomicrograph demonstrates the typical histological features in the affected epidermis, which demonstrates irregular hyperplasia with prominent rete ridges, epidermal hyperpigmentation, and moderate ortho/parakeratotic hyperkeratosis, with no significant inflammatory infiltrate.
Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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