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Carbon monoxide, parkinsonism induction, 397

CBD, see Corticobasal degeneration Charcot, Jean-Martin, Parkinson's disease research contributions, 11-13 Childhood onset parkinsonism, causes, 400 Cholinesterase inhibitors, dementia with Lewy bodies management, 368, 369 Computed tomography (CT)

progressive supranuclear palsy, 298, 440 vascular parkinsonism, 443 Computer modeling, basal ganglia disorders abnormal kinematics during pointing movement and errors in praxis bread-slicing gesture simulations, 104 cortical networks, 101

finger-to-nose test simulations, 102,

103 tasks, 99

behavioral operating characteristics, 95 hypokinetic disorders n Parkinson's disease, 97-99 limitations, 105, 106 neuropathology considerations, 96, 97 overview, 95, 96

paradigm of neural network modeling,

95, 96 prospects, 104, 105 Constipation, management, 477, 478 Corticobasal degeneration (CBD)

cholinergic defects and therapeutic targeting, 475 classification within parkinsonian disorders, 1, 2, 5, 6, 309, 498 clinical features alien limb phenomenon, 311 cognitive features, 312 cortical sensory loss, 311 dementia, 312 dystonia, 311

levodopa nonresponsiveness, 312, 329

mirror movements, 311 myoclonus, 311

progressive asymmetric rigidity and apraxia, 310, 311 tremor, 312 yes/no reversals, 312 clinicopathologic heterogeneity, 327, 328 diagnosis accuracy, 328, 329 criteria, 313-316 dopaminergic defects and therapeutic targeting, 474, 475 epidemiology, 310 eye movements, 242, 313 functional neuroimaging, 317, 465, 466 historical description, 18, 309 laboratory findings, 313, 316 limb apraxia, see Apraxia magnetic resonance imaging, 316, 317,

440, 442 management, 329, 330 neuropathology, 41, 43, 44, 119-121, 123, 317, 321

neuropsychological symptoms evaluation, 170-172, 188, 189, 312, 316 management, 176 progression, 3 research prospects, 330 speech and language disturbances clinical management, 259 language disturbances, 258, 259, 324 neuroanatomy, 257 speech disturbances, 257, 258, 324 syndromic features, 327 tau pathology, 145, 329 typical versus atypical forms, 122 visuospatial disorders, 221, 222 Web resources, 331 Creutzfeldt-Jacob disease, eye movements, 243

CT, see Computed tomography Cyanide, parkinsonism induction, 397

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