As discussed above, several of these non-degenerative forms of parkinsonism support the evidence for multiple etiologic factors leading to selective neuronal vulnerability.
Investigation of neuroprotective potential of specific agents such as CPI 1189 for HIV dementia has shown some improvement with motor function, but the study is not designed for efficacy (100). Future studies in this area may help treat HIV-induced parkinsonism. Parkinsonism induced by toxic exposure or specific infectious etiology may provide a direct clue to the dysfunction in mitochondrial and other specific cellular mechanisms such as inflammation, and lysosomal dysfunction, which may help identify specific targets for therapy. Further research into the cellular mechanisms in various types of parkinsonism are needed in order to clarify the mode of insult an specific signal transduction pathways involved in disease mechanisms.
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