- Parkinsonism may be associated with a variety of underlying pathologies.
- Most of the conditions that cause parkinsonism have damage of the striatonigral system as the anatomicopathological substrate.
- The most common causes of parkinsonism are neurodegenerative diseases, each of which has a defining pattern of neuropathology, often characterized by the abnormal accumulation of protein in the form of a cellular inclusion.
- For many of these conditions, recent molecular genetic findings have helped to define disease pathogenesis and have clarified the relationship between disease entities.
- Fig. 11. Wilson's disease. (A) Gross photograph showing cystic degeneration of putamen. (B) Alzheimer type II astrocytes with swollen pale nuclei (H&E stain). (C) Opalski cell (H&E stain).
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