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The Parkinson's-Reversing Breakthrough

Parkinson Disease Causes

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NBIA, see Neurodegeneration with brain iron accumulation Neurodegeneration with brain iron accumulation (NBIA) classification within parkinsonian disorders, 1, 2, 5, 6 clinical presentation, 387 gene mutations, 146, 148, 387 neuropathology, 49, 50 Neurofibrillary tangles (NFTs), comparative neuropathology of parkinsonism, 35 Neurophysiological assessment autonomic reflexes, 419, 420 bradykinesia, 410 brainstem reflexes eye and eyelid movements, 412-415 facial reflexes, 415 prepulse inhibition, 417 startle reaction, 415-417 dementia with Lewy bodies, 368 differential diagnosis of atypical parkin-

sonism, 422, 423 electromyography needle recording of sphincter muscles, 420 surface recording of abnormal movements, 417, 418 evoked potentials, 421, 422 hypokinesia, 410

progressive supranuclar palsy, 299, 300 research prospects, 423, 424 rigidity, 410-412 spinal reflexes, 417

transcranial magnetic stimulation, 421 Neuroprotection, therapeutic prospects,

479, 480 Neuropsychological evaluation basal ganglia neuropsychiatry, 163, 164 batteries, 163, 184

behavioral dysfunction management, 478, 479

corticobasal degeneration, 170-172, 188, 189

dementia with Lewy bodies, 168, 169, 189, 190

diagnostic value in parkinsonian disorders methodological considerations, 165168

overview, 190 multiple system atrophy, 172, 173, 187 Parkinson's disease, 186, 187 progressive supranuclear palsy, 169, 170,

187, 188 research prospects, 190 symptoms definition and identification, 162, 184, 185

epidemiology and implications in parkinsonian disorders, 164, 165 management corticobasal degeneration, 176 dementia with Lewy bodies, 175, 176

multiple system atrophy, 176 Parkinson's disease, 173-175 progressive supranuclear palsy, 176

measurement, 163, 184, 185 Neurosurgery, atypical parkinsonism management, 476 NFTs, see Neurofibrillary tangles Niemann-Pick disease, eye movements, 245

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