Nomenclature

The terminology relating to corticobasal degeneration (CBD) has been confusing. The following terms have been used: corticodentatonigral degeneration with neuronal achromasia (1,2), corticonigral degeneration (CND) (4), cortical-basal ganglionic degeneration (CBGD) (5), corticobasal ganglionic degeneration (CBGD) (6), and corticobasal degeneration (CBD) (7). Analyses from several academic centers have shown that the constellation of clinical features originally considered characteristic of this disorder can be seen in several non-CBD disorders, leading others to suggest syndromic terms such as corticobasal syndrome (3), corticobasal degeneration syndrome (8), Pick complex (9), progressive asymmetric rigidity and apraxia (PARA) syndrome (10), and asymmetric cortical degeneration syndrome-perceptual-motor type (11). Consensus on the terminology has not been established. In this review, the term corticobasal syndrome (and abbreviation CBS) will be used to characterize the constellation of clinical features initially considered characteristic of corticobasal degeneration, and the term corticobasal degeneration (and abbreviation CBD) will be used for the histopathologic disorder.

From: Current Clinical Neurology: Atypical Parkinsonian Disorders Edited by: I. Litvan © Humana Press Inc., Totowa, NJ

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