There is striking clinical and pathological overlap between PD and DLB. Up to one-third of patients with a clinical diagnosis of PD will develop dementia (9,12,42) and most (but not all) patients with DLB display some degree of parkinsonism (30). LBs are the defining histopathological feature of both conditions. In PD, LBs are most numerous in subcortical nuclei and it is the associated loss of dopaminergic neurons that is largely responsible for the characteristic extrapyramidal features. However, small numbers of cortical LBs may be found in virtually all cases of PD, even in the absence of dementia (31). In DLB, cortical LBs are usually more numerous and some studies have shown a
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