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The Parkinson's-Reversing Breakthrough

Treatment Options for Parkinson Disease

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Video 1: Voluntary saccades in Parkinson's disease. During the initial part of the clip, the patient is verbally instructed to look between two visual targets (a pen and the camera); some mild hypometria is evident. Subsequently, the patient is instructed to make self-generate saccades between two stationary targets about 60-80° apart; hypometria becomes much more marked, as well as some delayed in initiation.

Video 2: Vertical saccades in PSP. The patient is looking between two stationary targets about 40° apart in the vertical plane. The movements are slow, but carry the eyes to their targets. Their trajectories are slightly oblique or curved with a horizontal correction at the end ("round the houses") (50).

Video 3: Horizontal saccades in PSP. The patient is looking between two stationary targets separated about 60° in the horizontal plane. Horizontal saccades are faster than vertical saccades (Video 2), but tend to be hypometric.

Video 4: Light-induced blink response in a patient with PSP. This was tested by flashing a penlight repetitively into one eye at 1-2 Hz, as he viewed a distant target with both eyes. Unlike normals, or patients with PD, no habituation occurred.

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