An Inhibitory GABAergic Synapse

A GABA-ergic synapse employs y-aminobutyric acid (GABA) as its neurotransmitter. Amino acid neurotrans-mitters work by the same mechanism as ACh—binding to ion gates and causing immediate changes in membrane potential. The release of GABA and binding to its receptor are similar to the preceding case. The GABA receptor, however, is a chloride channel. It responds by opening

Saladin: Anatomy & 12. Nervous Tissue Text © The McGraw-Hill

Physiology: The Unity of Companies, 2003 Form and Function, Third Edition

Chapter 12 Nervous Tissue 467

  • Presynaptic neuron
  • Presynaptic neuron
Adrenergic Neurons ReleaseAdrenergic Neurons Release
Presynaptic neuron Postsynaptic neuron

Neurotransmitter receptor

Norepinephrine

|—Adenylate cyclase

Neurotransmitter receptor

Norepinephrine

|—Adenylate cyclase

Adrenergic Neurons Release

Enzyme activation

Metabolic changes t

Enzyme activation

-

Multiple possible effects

1

1 Genetic transcription

Enzyme synthesis

Figure 12.19 Transmission at a Cholinergic Synapse.

Acetylcholine directly opens ion gates in the plasma membrane of the postsynaptic neuron. Numbered steps correspond to the description in the text.

and admitting CP to the cell, making the inside of the cell even more negative than the resting membrane potential, and thus making the neuron less likely to fire.

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