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Figure 3.20. Yellow staining of the teeth in a child exposed to maternal tetracycline in utero.

Figure 3.19. The same infant with fetal valproate syndrome as shown in Figures 3.16 to 3.18, had distal phalangeal hypoplasia and tapering of the fingers. Note the abnormal creases on the fingers and palm due to lack of fetal movement in utero. Other changes reported in infants with this syndrome include tracheo-malacia, congenital heart defects, and urogenital anomalies.

Figure 3.20. Yellow staining of the teeth in a child exposed to maternal tetracycline in utero.

Figure 3.21. A Wood's filter shows the fluorescence of the nails in an infant exposed to maternal tetracy-cline. If young infants are given tetracycline after birth the staining of the teeth and nails also occurs.

Figure 3.22. Drug-induced pseudohermaphroditism in a female infant who was virilized by progestational agents during the first trimester of pregnancy. The incidence of this condition has decreased because, with recognition of this iatrogenic cause of virilization of the fetus, there has been a decreased use of incriminating drugs such as progestational agents or androgens during the first trimester. There may be fusion of labioscrotal folds with formation of a urogenital sinus and clitoromegaly. (See Volume V, chapter 5).

Figure 3.22. Drug-induced pseudohermaphroditism in a female infant who was virilized by progestational agents during the first trimester of pregnancy. The incidence of this condition has decreased because, with recognition of this iatrogenic cause of virilization of the fetus, there has been a decreased use of incriminating drugs such as progestational agents or androgens during the first trimester. There may be fusion of labioscrotal folds with formation of a urogenital sinus and clitoromegaly. (See Volume V, chapter 5).

Figure 3.23. The thalidomide syndrome in twin infants born to a mother who took thalidomide early in gestation. Maternal ingestion of thalidomide between the 25th to 44th day after conception may cause malformations. In the thalidomide syndrome the limbs are usually asymmetrically involved and the malformations of the extremities are of all grades of severity (digits are usually present). There may be microph-thalmia, ear deformities, and cardiac, renal and intestinal malformations.

Figure 3.23. The thalidomide syndrome in twin infants born to a mother who took thalidomide early in gestation. Maternal ingestion of thalidomide between the 25th to 44th day after conception may cause malformations. In the thalidomide syndrome the limbs are usually asymmetrically involved and the malformations of the extremities are of all grades of severity (digits are usually present). There may be microph-thalmia, ear deformities, and cardiac, renal and intestinal malformations.

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