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Neurodegenerative Disorders And Oxidative Stress Amyotrophic lateral sclerosis (Lou Gehrig's disease) 4. The substantia nigra and globus pallidus are rich in iron yet cerebrospinal fluid has very little iron-binding capacity (H2). Moreover, any injury to the CNS may result in the release of iron, which by Fenton Haber-Weiss chemistry, catalyzes free radical production. Iron has also been shown to accelerate the production of CNS lipofuscin (increased in Alzheimer's disease), while various...