Haemophilus ducreyi

Chancroid is a genital ulcer caused by Haemophilus ducreyi and is prevalent mainly in developing countries. Detection and treatment of genital ulcer disease have become increasingly important because of strong associations with increased risk of transmission of human immunodeficiency virus (HIV) infection (Pepin et al., 1992; CDC, 2002). As the disease can very often be definitively diagnosed only by isolation of the bacterium from the genital ulcer, this disease is probably un-derdiagnosed. Several studies have shown that the accuracy of clinical diagnosis for chancroid ranged from 33% to 80% (Dangor et al., 1990; Chapel et al., 1977). A definitive bacteriological diagnosis of the disease requires identification of the bacteria on specially prepared culture media that is not widely available from commercial sources. Even in experienced and well-equipped laboratories, the optimal sensitivity of bacteriological culture can only be up to 50% to 90% of clinically diagnosed chancroid cases (Dylewski et al., 1986; CDC, 2002). Because of lack of a gold standard on the diagnosis of chancroid, the sensitivity of culture can only be estimated.

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