Cyproterone Acetate

Cyproterone acetate is available in many parts of the world, but not in the United States. It possesses dual activity in that it serves as a progestogen in oral contraceptives in addition to its direct inhibition of the androgen receptor. It can be given in doses of 2 to 100 mg per day as a single agent, in which case there can be improvement in 75% to 90% of women with acne. Cyproterone acetate, however, is most commonly used in the form of an oral contraceptive combined with ethinyl estra-diol in varying doses (38). Numerous clinical studies support the efficacy of these oral contraceptive preparations in women with acne.

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