Expression of IL-1a and b was demonstrated in sebaceous glands by immunohis-tochemistry (162), and mRNA for IL-1a was detected in cultured sebocytes (163). No change in staining pattern was observed when sebum was extracted from the samples, indicating that IL-1 is not associated with sebum. The function of IL-1 in normal sebaceous glands is unclear, although in vitro IL-1a and tumor necrosis factor a, inhibited sebaceous lipogenesis in sebaceous gland organ culture and induced de-differentiation of human sebocytes into a keratinocyte-like phenotype (152). In organ culture, IL-1a at 1 ng/mL promoted ductal cornification (164) and upregulated mRNA and protein synthesis of vascular endothelial growth factor (VEGF) (165). Thus in follicular diseases, liberation of IL-1 into the dermis may contribute toward inflammation and increased levels of VEGF by follicular kerati-nocytes can stimulate angiogenesis. In acne, high levels of IL-1 a bioactivity existed in comedonal contents (166).

Fight Acne

Fight Acne

I am sure that every one of you is familiar with acne. Almost all of us got this skin disorder, right? Well, technically known as acne vulgaris, this skin disorder affects millions of people from different walks of life, annually.

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