Gonadotropin Releasing Agonists

Androgen production in the ovary can also be blocked by gonadotropin-releasing hormone agonists such as buserelin, nafarelin, or leuprolide. These gonadotropin-releasing agonists block ovulation by interrupting the cyclic release of FSH and LH from the pituitary. These drugs are efficacious in acne and hirsutism, and are available as injectable drugs or nasal spray. However, in addition to suppressing the production of ovarian androgens, these drugs also suppress the ovarian production of estrogens, thereby eliminating the function of the ovary. Thus, the patient could develop meno-pausal symptoms and suffer from hypoestrogenism. Headaches can also develop, as well as the occurrence of bone loss, due to the reduction in estrogen.

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