Growth hormone is secreted by the pituitary gland. It acts on the liver and peripheral tissues to stimulate the production of IGFs, formerly known as somatomedians. There are two forms of IGF, termed IGF-1 and IGF-2. IGF-1 is the more prevalent growth factor. It has been hypothesized that growth hormone may be involved in the development of acne (29). Acne is most prevalent in adolescents during a time when growth hormone is maximally secreted and serum levels of IGF-1 are highest. In addition, IGF-1 can be produced locally within the skin, where it can interact with receptors on the sebaceous gland to stimulate its growth. Furthermore, conditions of growth hormone excess such as acromegaly are associated with sebor-rhea and the development of acne. In some tissues, the actions of IGF-1 can be mediated by androgens. It is possible that androgens may influence IGF-1 action in the sebaceous gland as well.
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