GnRH agonists

As analogues of GnRH (gonadotropin-releasing hormone) agonists suppress LH (luteinising hormone) and FHS (follide-stimulating hormone) secretion from the pituitary. This results in ovarian suppression and significant reduction in the secretion of oestrogen, which results in thinning of the endometrium. They are generally only given for a 6-month period, as 6 per cent of bone mineral density may be lost in the first 6 months. It takes two years for the loss to be restored. It can provide up to 90 per cent relief of symptoms in patients.

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