Jarisch Herxheimer reaction

  • This is thought to be due to the release of endotoxins from ruptured spirochaetes in patients being treated for syphilis.
  • The reaction can affect 50-80 per cent of patients.
  • It starts 3-6 hours after administration of the initial dose of procaine ben-zylpenicillin. The reaction will usually resolve within 24 hours.
  • Symptoms are flu-like and involve fevers, chills, sore throat, headache, malaise, exacerbation of lesions or outbreak of new lesions. Nausea, vomiting and arthralgia have also been reported.
  • Patients should be counselled to take paracetamol for relief of symptoms and be reassured that the reaction is transient.

CEPHALOSPORINS

Cephalosporins are related to penicillins and also belong to the beta-lactam group of antibiotics. There is a 10 per cent cross-sensitivity in allergic patients. Over a hundred different types of cephalosporins are in existence. They are broadly similar, but can differ in bioavailabililty, pharmacokinetics and antibacterial activity.

0 0

Post a comment