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Patches, plaques and tumours can be found. Preferential location buttocks, other sun-protected areas (early phases). Rarely observed in children (but the most common cutaneous lymphoma in this age group ). Morphology Small pleomorphic (cerebriform) cells. During the course of the disease large cell transformation may occur indicating a worse prognosis (immunoblasts, large cell anaplastic, large cell pleomorphic). Immunology CD2, 3, 4, 5, 45RO + CD8, 45RA CD30 may be positive in...

Histopathology immunophenotype and molecular genetics

The histopathological features of cutaneous manifestations of lymphomatoid granulomatosis depend on the grade of disease and type of lesion. In some cases, only a non-specific perivascular and periadnexal infiltrate of small- to medium-sized cells can be seen. Cutaneous tumours of lymphomatoid granulomatosis are characterized usually by the presence of an angiocentric angiodestructive infiltrate with variable numbers of large B lymphocytes (Figs 15.8a,b). Granulomat-ous features are often...

Persistent nodular arthropod bite reactions

The most typical example of this group of lymphomatoid infiltrates is nodular scabies but many other arthropods can induce skin lesions that may simulate malignant lymphoma histopathologically. Clinically, in nodular scabies, elevated round or oval bright reddish papules and nodules occur most frequently on the genitalia, elbows and in the axillae (Fig. 20.34). The lesions are found in approximately 7 of patients with scabies. The nodules are very pruritic and may persist for many months. The...

Lymphocytoma cutis

Borrelia Burgdorferi Entering Body

Several synonyms have been used for lymphocytoma cutis including lymphadenosis benigna cutis, cutaneous lympho-plasia, cutaneous lymphoid hyperplasia and pseudolymphoma of Spiegler-Fendt. Various antigenic stimuli can induce these lesions insect bites, drugs, vaccinations, acupuncture, wear- Fig. 20.25 Lymphomatoid drug eruption, T-cell type. Note several atypical lymphocytes and one mitotic figure (detail of Fig. 20.24). Fig. 20.25 Lymphomatoid drug eruption, T-cell type. Note several atypical...

Other cutaneous pseudolymphomas

Hemangioma Scalp Infant Histology

Besides the cutaneous pseudolymphomas discussed in the Fig. 20.46 Reactive angioendotheliomatosis (intravascular histiocytosis). Dilated blood vessels in the superficial dermis, some filled with large histiocytes, simulating the picture of intravascular large cell (angiotropic) lymphoma. previous paragraphs, the occurrence of other skin conditions simulating clinically and or histopathologically cutaneous lymphomas has been reported sporadically. Cases of inflammatory lesions of vitiligo and of...

Lupus panniculitis

Tcell And Cell Sle

Patients with lupus erythematosus may rarely present with prominent involvement of the subcutaneous tissues, a condition that has been termed lupus panniculitis or lupus profundus. Lupus panniculitis reveals subcutaneous plaques and indurations, mostly located on the extremities, which can simulate clinically and histopathologically those observed in subcutaneous T-cell lymphoma (see Chapter 5) (Fig. 20.20) 57 . Antinuclear antibodies and other criteria for the diagnosis of systemic lupus...

Subcutaneous Tcell lymphoma

A degree of involvement of subcutaneous fat by neoplastic lymphocytes is common in many primary or secondary cutaneous T- and B-cell lymphomas. One particular variant of T-cell lymphoma presents with predominant or exclusive involvement of the subcutaneous tissues and has been termed subcutaneous 'panniculitis-like' T-cell lymphoma in recent years 1,2 . In our view, the term 'panniculitis-like' is redundant and we will refer to this entity henceforth as 'subcutaneous T-cell lymphoma'....

Szary syndrome

Sezary syndrome is characterized clinically by pruritic erythroderma, generalized lymphadenopathy and the presence of circulating malignant T lymphocytes (Sezary cells) 1-3 . Other typical cutaneous changes include palmoplantar hyperkeratosis, alopecia and onychodystrophy 4 . Differentiation from non-neoplastic erythroderma may be extremely difficult. The main causes of erythroderma, besides cutaneous T-cell lymphoma, are atopic dermatitis, psoriasis and drug reactions 5 . Erythrodermic mycosis...

Lymphomatoid contact dermatitis

Pautrier Microabscesses

The term lymphomatoid contact dermatitis was coined by Gomez Orbaneja etal. 33 in 1976. These authors described four patients with persistent allergic contact dermatitis proved by patch tests. The clinical picture and histological features in their patients were highly suggestive of mycosis fungoides. Clinically, lymphomatoid contact dermatitis is characterized by pruritic erythematous plaques (Fig. 20.3). Generalized plaques or exfoliative erythroderma can be observed rarely. The lesions...

Pseudolymphomas of the

Pseudolymphomas of the skin are benign lymphocytic proliferations that simulate cutaneous malignant lymphomas clinically and or histopathologically 1-5 . The term pseu-dolymphoma is not specific but is merely descriptive as it encompasses reactive skin conditions with different aetiologies, pathogeneses, clinicopathological presentations and behaviours. Cutaneous pseudolymphomas are traditionally divided into T- and B-cell pseudolymphomas according to the histopathological and...