Secondary syphilis

Rarely, cutaneous lesions in secondary syphilis may show dense lymphoplasmacellular infiltrates simulating histopath-ologically the picture of a marginal zone B-cell lymphoma (Figs 20.41 & 20.42) [90,91]. These plasma cells always reveal a polyclonal pattern of immunoglobulin light-chain

Fig. 20.40 Acral pseudolymphomatous angiokeratoma (small papular pseudolymphoma). Nodular lymphoid infiltrate in the superficial and mid-dermis of acral skin.

Fig. 20.41 Pseudolymphoma in secondary syphilis. Dense nodular lymphoid infiltrates throughout the entire dermis.

SEK* *

  • gt;Ä;V iff V' •«{.& v ;
  • i«^«*«!/! Jfl iL * kl1

Fig. 20.42 Pseudolymphome in secondary syphilis. Lymphocytes and histiocytes admixed with several plasma cells (detail of Fig. 20.41).

Fig. 20.43 Inflammatory pseudotumour of the skin (inflammatory myofibroblasts tumour). Large reddish tumour on the scalp with crusts.

expression. Correlation with the clinical picture and posi-tivity of serological tests for syphilis confirm the diagnosis. Antibiotic treatment leads to a rapid resolution of the lesions.

Was this article helpful?

0 0

Post a comment