Treatment and prognosis

Patients with specific cutaneous manifestations of Hodgkin lymphoma should be treated in a haematological setting according to schemes tailored for the underlying disease.

In the past, the prognosis for patients with skin manifestations of nodal Hodgkin lymphoma was poor in spite of aggressive treatment. Modern treatment modalities have resulted in a decline in the onset of specific skin manifestations. Because only occasional patients present with cutaneous involvement, there is little information on which to base prognosis and therapeutic options. However, cutaneous Hodgkin lymphoma usually represents advanced (stage IV) disease and carries a bad prognosis.

RÉSUMÉ

Clinical

Adults. Solitary

, grouped or,

rarely,

generalized cutaneous papules, plaques and

tumours.

Lesions are commonly

located at the drainage

area of affected lymph nodes

Morphology

Nodular or diffuse infiltrates

characterized by

presence of Reed-Sternberg

and Hodgkin

cells on a background

of small lymphocytes,

histiocytes and

eosinophils.

Immunology

CD3G +

CD15 + (-)

Genetics

Data on genetic features of specific skin

manifestations

are not available.

Treatment

Treatment planned or

the basis of the

guidelines

underlying disease.

Radiotherapy of isolated skin

tumours.

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