One of the most important developments in the LT area relates to atherogenesis where several different studies have implicated LTs in disease progression [29]. 5-LO, FLAP and LTA4 hydrolase are expressed in human atherosclerotic lesions [34]. LTB4 stimulates the expression of genes related to atherogenesis in rat basophilic leukemia cells [35]. Using mouse genetic models of atherogenesis (apo-E_/_ or LDLR_/_), the treatment with LTB4 antagonists [36], the deletion of 5-LO [37] and deletion of the BLT1 receptor [35] were found to reduce disease severity. The 5-LO gene was identified as part of the gene cluster on chromosome 6 conferring resistance to atherogenesis in the mouse strain CAST [37]. A congenic strain, containing the athero-resistant chromosome 6 region, was found to express 5-LO at reduced levels [37]. The deduced sequence for 5-LO from the atherosclerosis resistant mice contained mutations that affected enzyme activity when introduced into the human enzyme [38]. A polymorphism in the 5-LO gene promoter has recently been identified in relation to increased atherosclerosis [39].

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Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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