In vivo infection models

Two in vivo efficacy models in guinea pigs have been reported. In the first study, the authors infected the nails and toes of guinea pigs creating both onychomycosis and tinea pedis (fungal infection of the surrounding skin). They then used this model to show the efficacy of a topically applied triazole in comparison with amorolfine and terbinafine. All three were effective in clearing the tinea pedis, but only the experimental triazole showed efficacy against onychomycosis [27]. The second model was developed as an optimized in vivo model for dermatophytosis. The authors shaved and abraded the skin on the back of guinea pigs and infected the site with T. mentagrophytes. After the infection was established, the animals were treated with oral and topical formulations of terbinafine and observed for improvement of the infection [56]. In this study, 1% topical terbinafine treatment had 100% clinical and mycological efficacy. Although this is a model for dermatophytosis, this model was used to determine the efficacy of a topical lacquer formulation of terbinafine.HCl, currently in clinical development for onychomycosis [57].

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