Leads discovered by virtual screening

Computational screening of a 3D structure database of natural products was the starting point for the discovery of embelin, 34, isolated from the Japanese Ardisia herb [85]. Embelin binds the BIR3 domain of XIAP with an IC50 = 4.1 mM and NMR analysis confirms several key interactions with residues crucial for binding to SMAC and caspase-9. Embelin (25-50 mM) induces cell death and caspase-9 activation in PC-3 prostate cancer cells with high XIAP expression levels. In XIAP-transfected Jurkat cells, embelin (50 mM) reverses the protection afforded by overexpression of XIAP against etoposide-induced apoptosis.

Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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