New Biology And Pharmacology Of The Leukotriene Pathway

The LTs are generated by the initial conversion of AA to LTA4 by 5-LO and FLAP which is further converted by LTA4 hydrolase to LTB4 or by LTC4 synthase to yield the cysteinyl-LTs, LTC4, LTD4 and LTE4. Receptors for LTB4 (BLT1) and LTD4 (cystLT1) have been previously described [26,27]. Mice deficient in BLT1 have been generated and the use of these mice in models of allergic pulmonary inflammation has demonstrated the role of this receptor in T cell recruitment [28]. Recent developments in the molecular biology of the pathway include the cloning of a second low affinity form of the LTB4 receptor (BLT2) and of a second cysLT receptor (cysLT2), both of which have distinctive agonist and antagonist binding properties and patterns of tissue expression compared the previously identified receptors [29].

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Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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