Inhibit expression of viral mRNAfincrease resistance to virus
Viral mRNA/neighboring host cells
Piramaviruses (enteroviruses and rhinoviruses)
Inhibit attachment and uncoating of virus
Binds to virus
CJW Cytomegalovirus; Mlfhur
nan immunodeficiency virus; HSV, herpes simplex virus; KZli varicella zos
1er virus; RSV, respiratory syncytial virus; HCV, hepatitis G vims.
they can reactivate, causing symptomatic, even fatal, disease.
Adenoviruses (Table 51-4) were first isolated from human adenoid tissues. At present, approximately 50 serotypes of human adenoviruses have been described; however, most disease is associated with only one third of these types. Adenoviruses cause less than 5% of all acute respiratory disease in the general population, m. addition, adenovirus serotypes 40 and 41 cause gastro* enteritis in infants and young children, and other sero-type£\cause conjunctivitis and keratitis. Compromise^ hosts )may develop disseminated, multiorgan systems disease. Laboratory diagnosis is accomplished most corte monly by conventional or rapid cell culture using HEp-^ cells.
Table 51 -3 List of Viral Syndromes and Common Viral Pathogens
Parainfluenza, respiratory syncytial, metapneumovlrus Respiratory syncytial, parainfluenza, metapneumovirus Respiratory syncytial, adenovirus, influenza, parainfluenza
Influenza, adenovirus, sin nombre virus (hantavirus), SARS Coronavirus
Mumps, parainfluenza Coxsackie B and echoviruses
•zoster, adenovirus, enterovirus 70
Encephalitis and other viruses
Viral Syndrome Intents and Children
Table 51 -4 Adenoviruses
Characteristics: Double-stranded DNA genome; icosahedral capsld.no envelope; approximately 50 human serotypes Transmission: Respiratory, fecal-oral, and direct contact (eye) wes
Site of latency: Replication in oropharynx
Prevention: Vaccine (adenovirus serotypes 4 and 7) for military recruits
Upper respiratory tract infection Pharyngitis
Rhinovirus, Coronavirus, adenovirus, influenza, parainfluenza, Epstein-Barr
Upper respiratory tract infection
Febrile illness with rash
Hemorrhagic cystitis Cutaneous infection with or without rash
Hemoirhagic fever Generalized, no specific target organ
Rhinovirus, Coronavirus, parainfluenza, adenovirus, respiratory syncytial, influenza Adenovirus, Coxsackie A herpes simplex, Epstein-Barr virus, riiinovirus, parainfluenza, influenza
Parainfluenza, respiratory syncytial, metapneumovlnjs
Rotavirus, adenovirus 40-41, calicivlrus, astrovims HSV-2, echovirus, and other enteroviruses, CMV, parvovirus B19, VZV, HIV, hepatitis viruses
Gastroenteritis Congenital and neonatal disease
All Patients enter0Vlruses'meas,e8'mMa' P^vovirus B-19, human herpesvirus 6 and 7, HPV poxviruses including smallpox, monkeypox, molluscum contegiosum. and orf
Echoviruses and coxsackie viruses, mumps, lymphocytic choriomeningitis, HSV-2 HSV-1, togaviruses, faunyaviruses, flaviviruses, rallies, enteroviruses, measles, HIV, JC virus Hepatitis A, B, C, D (delta agent), E, and non-A, B, C, D, E Adenovirus, BK virus
Table 51-6 Bunyaviruses
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This fact sheet is designed to provide you with information on Bacterial Vaginosis. Bacterial vaginosis is an abnormal vaginal condition that is characterized by vaginal discharge and results from an overgrowth of atypical bacteria in the vagina.