specific but may not be as sensitive for detecting small quantities of antigen as latex agglutination, thus, it is not usually used for direct antigen detection.
Phospholipid molecules form small, closed vesicles under certain controlled conditions. These vesicles, consisting of a single lipid bilayer, are called liposomes. Molecules bound to the surface of liposomes act as agglutinating particles in a reaction. By combining liposomes containing reactive molecules on their surfaces and latex particles that harbor antibody-binding sites on their surfaces, reagents are created that have the potential to transform a weak antigen-antibody particle agglutination reaction into a stronger, more easily visualized reaction (Figure 9-9). Liposomes have yet to reach their full potential as diagnostic reagents in clinical microbiology.
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