Treadmill Cardio Workouts
Spinal cord stimulation (SCS) has been proposed as a novel treatment strategy that may be effective in end-stage ischemic heart disease patients with intractable angina. The efficacy of spinal cord stimulation on the relief of otherwise intractable angina pectoris was studied in a 2-mo randomized study with 1-yr follow-up by quality-of-life parameters, cardiac parameters, and complications. Twenty-four patients were randomized to either an actively treated group A (12 patients received the device within a 2-wk period) or a control group B (10 patients had implantation after the study period). Spinal cord stimulation improved both quality-of-life and cardiac parameters. The latter included a trend towards reduction in ischemia after implantation of the device in both exercise testing with a treadmill (ETT) and 24-h ambulatory Holter recordings, with a concomitant improvement in exercise capacity (55). Indices of ischemia were studied with and without SCS in 10 patients with otherwise...
The negative externalities of pesticide use were subject to serious criticism, mainly stimulated by the publication of Rachel Carson's Silent Spring in 1962 and by the assessment of Pimentel and others (1986, 1993). Proponents of GMOs see these plants as the most promising way to escape the pesticide treadmill and as a necessity to overcome the world's food problem. For example, The Economist (1999) warned policymakers against slowing the development of GMOs in response to public panic about perceived health risks, pointing to their economic benefits for agriculture.
Appropriate pesticide resistance management strategies are part of such a strategy. The threats of resistance and the induced increased risk of pest outbreaks can put farmers on a pesticide treadmill leading them to use ever-increasing amounts and stronger pesticides to kill mutating pests with severe consequences (van den Bosch 1978). Resistance is increasingly perceived as an important constraint to effective crop protection that limits the prospects for matching the projected increase in global food demand, especially in developing countries (Yudelman et al. 1998). Therefore, resistance management is in the interest of the agricultural community (Nevill et al. 1998). Manufacturers of plant protection products have established a number of industrywide public-private committees for information exchange and to create awareness about resistance management (GCPF 2000).
The recently reported REVASC trial is the largest clinical trial in humans to date evaluating the efficacy of adenovirus-mediated VEGF (Ad.VEGF121) gene therapy for myocardial ischemia (75). In this phase 2, randomized, multicenter trial, 67 patients were randomized to receive AdVEGF121 administered by direct intramyocardial injections via a limited thoracotomy or to continue with optimal medical management. At 26 wk, time to ischemia on treadmill testing was significantly increased in the AdVEGF121 versus the medical therapy group (p 0.024). There were significant improvements in anginal status as well as in several domains of the Seattle Angina Questionnaire in the AdVEGF121 compared to the medical therapy group. Although these data are encouraging, four patients in the AdVEGF121 group suffered cardiac complications as a result of the thoracotomy.
Additional functional test assessment using exercise tolerance was also performed in three of the trials (3,16,17). Although the method of treadmill testing differed between the trials, the results demonstrate an improvement in exercise tolerance for TMR-treated patients. Two studies showed an average of 65- to 70-s improvement in the TMR group at 12 mo compared to baseline, while the medical management group had either an average of 5-s improvement or a 46-s decrease in exercise time over the same interval (16,17). One additional trial demonstrated that the time to chest pain during exercise increased significantly and fewer patients were limited by chest pain in the TMR group, whereas the medical management group showed no improvement (17).
Run for Your Life The Health Benefits Of Treadmills
Improve your hearts health? Lose a few pounds? Or simply become more active? If that is your goal, then maybe its time for you to do some exercise. But where do you start?