Small GTPase Activation and Epithelium Destruction

It is not clear how tissue damage affects the infection process, but it could be important for evasion of the immune system or access to deeper tissues or for favoring bacterial dissemination to another host. In any case, it is thought to be involved in H. pylori-triggered pathological symptoms associated with epithelium destruction such as peptic ulcer and could be involved in cancer development, as the morphological changes induced by H.pylori resemble the process of oncogenic transformation.

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